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艾滋病毒HIV是特異性感染人的CD4陽性T細胞的，一直難以獲得可用的小動物模型。人源化免疫系統小鼠模型，如HSC-NPG、BLT-NPG，體內可分化出較高比例的人源CD4陽性T細胞，可以被HIV感染，且模型穩定期較長，為艾滋病的研究和抗病毒藥物研發提供了理想的模型。
圖1 在感染HIV（Bal-1株）的HSC-NPG模型鼠上評價基因編輯的HSC移植對HIV感染的治療潛力。
應用領域
-造血、免疫學研究
-血液病研究
-艾滋病等血液系統感染病研究
-移植免疫研究
-腫瘤免疫研究
-基因治療研究
參考文獻
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（5）Liu X, Zhang Y, Cheng C, et al. CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells. Cell Res. 2017 Jan;27(1):154-157.
（6）Zhang Y, Zhang X, Cheng C, et al. CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells. Front Med. 2017 Dec;11(4):554-562.
（7）Xu L, Yang H, Gao Y, et al. CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo. Mol Ther. 2017 Aug 2;25(8):1782-1789.
（8）Sun Q, Zhou S, Zhao J,et al. Engineered T lymphocytes eliminate lung metastases in models of pancreatic cancer. Oncotarget. 2018 Jan 10;9(17):13694-13705.
（9）Wei J, Luo C, Wang Y,et al. PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity. J Immunother Cancer. 2019 Aug 7;7(1):209.
